Fig. 3
From: Unveiling the mechanisms and challenges of cancer drug resistance
pH change and cellular organelle's role in drug resistance. Resistant Cancer cells change extracellular (ECM) as well as intracellular (cytosol, subcellular organelles) pH according to their requirement thus activating various pathways which cause metabolic, genetic, epigenetic rewiring to support their survival, metastasis, and drug resistance. Figure created with ChemBioDraw Ultra 14.0