Fig. 5

FBLN5 overexpression leads to inhibition of MYC in COS-7 cells but not in CV-1 cells. a-c IPA Comparative pathways analysis between the differentially expressed gene sets in wild type COS-7 cells vs wild type CV-1 cells (COS-7 vs CV-1), FBLN5-transfected COS-7 vs wild type COS-7 cells (COS7 FBLN5) and FBLN5-transfected CV-1 vs wild type CV-1 cells (CV1 FBLN5). The dot represents -log₁₀(p-value) ≤ 1.5 (below significance threshold). a IPA Canonical Pathways comparison analyses, heatmap cut off values: -log₁₀(p-value) ≥ 1.3, -log₁₀(B-H (Benjamini-Hochberg) p-value) ≥ 2 and activation z-score ≥ 2.5. b IPA Downstream Effects comparison analyses, heatmap cut off: -log₁₀(p-value) ≥ 1.3, -log₁₀(B-H p-value) ≥ 1.3 and activation z-score ≥ 2.5. c IPA Upstream Regulator comparison analyses, heatmap cut off: -log₁₀(p-value) ≥ 1.3, -log₁₀(B-H p-value) ≥ 1.7 and activation z-score ≥ 3.5. The predicted upstream regulation of MYC between three conditions is pointed out. A differential gene expression analysis filter comprising fold change ≥ 2 and ≤ -2, p ≤ 0. 05 and FDR ≤ 0.05 was used in all cases