Table 1 Histone methyltransferase and demethyltransferase
| Â | Â | Class | Name | Site |
|---|---|---|---|---|
Histone methyltransferase | histone lysine methyltransferase (HKMT) | KMT1 | SUV39H1/2 G9a EHMT1 GLP SETDB1/2 CLLD8 | H3K9 |
KMT2 | SET1A/B MLL1-5 ASH1L | H3K4 H4K20 H3K9 | ||
KMT3 | NSD1 SET2 SYMD2 | H4K20 H3K36 | ||
KMT4 | DOT1L | H3K79 | ||
KMT5 | SET8 SUV4-20H1/2 | H4K20 | ||
KMT6 | EZH1 EZH2 | H3K27 | ||
KMT7 | SET7/9 | H3K4 | ||
KMT8 | PRDM2 PRDM3 PRDM8 PPRDM16 | H3K9 | ||
protein arginine methyltransferase, PRMT | Â | PRMT1 | H4R3 | |
PRMT2 | H3R8 | |||
PRMT3 | Â | |||
PRMT4( CARM1) | H3R2 H3R17 H3R26 | |||
PRMT5 | H3R8 H4R3 | |||
PRMT6 | H3R2 H4R3 | |||
PRMT7 | H4R3 | |||
PRMT8 | Â | |||
PRMT9 | Â | |||
Histone demethyltransferase | Lysine-specific demethylase, LSD | LSD1 | KDM1A | H3K4 H3K9 |
LSD2 | KDM1B | H3K4 | ||
JMJD (JmjC domain-containing family) | KDM2 | JHDM1A (KDM2A) JHDM1B (KDM2B) | H3K36 H3K4 | |
KDM3 | KDM3A KDM3B JMJD1C | H3K9 | ||
KDM4 | KDM4A KDM4B KDM4C KDM4D | H3K9 H3K36 | ||
KDM5 | KDM5A KDM5B KDM5C KDM5D | H3K4 | ||
KDM6 | UTX JMJD3 UTY | H3K27 | ||
KDM7 | JHDM1D PHF8 | H3K9 H4K20 |