Table 1 The applications of nanomaterials to target tumor ferroptosis
From: Targeting ferroptosis in melanoma: cancer therapeutics
Nanomaterials | Target | Mechanisms of action | References |
|---|---|---|---|
SRF@FeIIITA | GPX4 | Inhibit GPX4 enzyme for ferroptosis initiation | [67] |
AMSNs | GSH, GPX4 | Highly efficient glutathione (GSH) depletion ability | [70] |
FeGd-HN@Pt@LF/RGD2 | GPX4 | Accelerate Fenton reaction and generates ROS to induce ferroptosis | [68] |
SPFeN | GPX4 | Generates hydroxyl radicals and accelerates the Fenton reaction | [72] |
Fe3O4-PLGA-Ce6 | GSH, GPX4, SLC7A11 | Accelerate Fenton reaction and generates ROS to induce ferroptosis | |
LDL-DHA | GPX4 | Experience pronounced lipid peroxidation, depletion of glutathione, and inactivation of GPX4 | [73] |