Fig. 2
From: Targeting ferroptosis in melanoma: cancer therapeutics
Ferroptosis cell death process. Ferroptosis is triggered by direct suppression of system Xc- or GPX4, which ultimately results in cell death. The ferroptosis process involves lipid ROS. On the one hand, PUFA peroxidation is thought to be a key element. In contrast, the execution of ferroptosis is based on iron overload