Fig. 1
From: Targeting ferroptosis in melanoma: cancer therapeutics
The main morphologic characteristics of cell death are apoptosis, pyroptosis, ferroptosis, and Necrosis. Apoptosis is characterized by DNA condensation and fragmentation, and the occurrence of apoptotic body. Cells with pyroptosis present DNA condensation and fragmentation, and the membrane is ruptured. Ferroptosis is defined as free iron accumulation, lipids peroxidation, ROS generation. Cells undergoing necrosis show DNA degradation and membrane rupture. Pyroptosis and necrosis are accompanied with cell membrane rupture and severe inflammatory reaction, while apoptosis and ferroptosis are devoid of these changes and there are no cell membrane alterations and no DNA fragmentation