Fig. 3
From: Castration promotes the browning of the prostate tumor microenvironment
Castration increases UCP1 levels and changes AR location in the PPAT. A UCP1 location in the PPAT of SHAM operated WT and TRAMP mice and after castration (CAST). Arrows shows positive immunolabeling in the brown/beige adipocytes. Images were taken at 40 and 400X of magnification. B UCP1 location in the white PPAT. Arrows shows positive immunolabeling for UCP1 in white adipocytes. Images were taken at 40 and 400X of magnification. C AR location in the PPAT of TRAMP and TRAMP castrated (CAST) mice. Arrow shows subcellular location of AR. Images were taken at 100 and 400X of magnification. D Upper panel: expression level of Ucp1 in WT and TRAMP animals after 12 weeks of castration (CAST) n = 6. Lower panel: expression levels of Ucp1 in TRAMP mice after 4 weeks of castration (CAST) and before 2.5 mg/Kg of testosterone administration (CAST + TEST) n = 5. Data are presented as mean ± SEM. * p < 0.05, ** p < 0.01