Fig. 1
From: Castration promotes the browning of the prostate tumor microenvironment
Castration induces Brown/beige adipose tissue in the prostate tumor microenvironment. A Effect of castration on the PPAT. Representative images of hematoxylin–eosin slides from WT and TRAMP mice after castration for 4 (CAST 4w) or 12 (CAST 12w). Arrow shows multilocular adipocytes depots. Images were taken at 400X of magnification. B Average size of white adipocytes. C WAT surface per total gland surface. D BAT/beige fat surface per total gland surface. E Brown/beige fat surface vs WAT surface ratio in SHAM operated and after for 4 (CAST 4w) or 12 (CAST 12w) of castration. F effect of 2.5 mg/Kg testosterone administration for 5 days in the PPAT.of TRAMP, TRAMP castrated (CAST), and TRAMP castrated plus testosterone (CAST + TEST). Arrow shows brown/beige fat depots. (*) Blood vessel. Images are taken at 100 and 400X of magnification. G BAT/beige fat surface per total gland surface after castration and testosterone administration. H Brown/beige fat surface vs WAT surface ratio after castration and testosterone administration. Figures A-E: n = 10. Figures F-G: n = 5. ND: non detectable. Data are presented as mean ± SEM. * p < 0.05, **p < 0.01, *** p < 0.001, **** p < 0.0001