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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Defective quality control autophagy in Hyperhomocysteinemia promotes ER stress and consequent neuronal apoptosis through proteotoxicity

Fig. 6

Hyperhomocysteinemic Drosophila melanogaster shows downregulation of the autophagy genes and upregulation of the stress response genes at systemic level. A Heat map illustrating RNA-Seq differential expression data for autophagy and stress response pathway genes in control versus CBS knockout (whole body) flies. Pairwise comparisons with wild type are shown. Red positive log fold change (log2FC). Blue negative log2FC. Heat map showing pathway specific expression of autophagy (B) and stress response (C) genes in the same knockout flies. Pairwise comparisons with wild type control strains are shown. Respective color legends representing log fold changes (log2FC). Three sets of data from 3 different wild type control and knockout flies (CBS-/-) were used for analysis.

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Cell Communication and Signaling

ISSN: 1478-811X