Table 1 Ligand specificity of FGFRs
From: Fibroblast growth factor signaling in axons: from development to disease
FGF4 Subfamily | FGF5 Subfamily | FGF8 Subfamily | FGF9 Subfamily | FGF10 Subfamily | FGF15/19 Subfamily | FGF11 Subfamily | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3 | 4 | 6 | 1 | 2 | 5 | 8 | 17 | 18 | 9 | 16 | 20 | 7 | 10 | 22 | 15 / 19 | 21 | 23 | 11 | 12 | 13 | 14 | |
FGFR1b | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |||||||||||||
FGFR1c | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |||||||||||
FGFR2b | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |||||||||||
FGFR2c | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||||||||||
FGFR3b | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |||||||||||||||
FGFR3c | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||||||||||
FGFR4 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||||||||||