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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: The role of bone marrow microenvironment (BMM) cells in acute myeloid leukemia (AML) progression: immune checkpoints, metabolic checkpoints, and signaling pathways

Fig. 2

The metabolism of an acute myeloid leukemia cell. Metabolic reprogramming produces ATP and intermediates for the biosynthesis of amino acids, nucleotides, lipids, and redox components which required for high proliferation rate. Flexible changes in nourishing and processing BMM and leukemic cells in ecological conditions propel significant differences in the AML BMM cells resulting in these substances happening in the preexisting metabolic pathways to AML advancement. GLUTs: glucose transporters; MCTs: monocarboxylate transporters; α-KG: α-Ketoglutarate; PPP: pentose phosphate pathway

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Cell Communication and Signaling

ISSN: 1478-811X