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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: The role of bone marrow microenvironment (BMM) cells in acute myeloid leukemia (AML) progression: immune checkpoints, metabolic checkpoints, and signaling pathways

Fig. 1

AML bone marrow microenvironment (BMM) cells’ immune checkpoints and component productions that contribute to angiogenesis, metastasis, and cell proliferation. The yellow concentric circle refers to cells component productions such as chemokines, cytokines, and growth factors. The purple concentric circle refers to immune checkpoints. TAM: tumor-associated macrophage; DC: dendritic cells; LIC: leukemia-initiating cell; MDSC: myeloid-derived suppressor cell; CAF: cancer-associated fibroblast; MSC: mesenchymal stromal cell; NK cell: natural killer cell; TNF-α: tumor necrosis factor-alpha; IL: interleukin; TGF-β: transforming growth factor-β; CCL: C–C motif chemokine ligand; CXCL: chemokine (C-X-C motif) ligand; NO: nitric oxide; SCF: stem cell factor; MMPs: matrix metalloproteinases; Ang: angiopoietin; IDO: indoleamine 2,3-dioxygenase; OPN: osteopontin; OCN: osteocalcin; VEGF: vascular endothelial growth factor; PDGF: platelet-derived growth factor; SDF: stromal cell derived factor; FGF: fibroblast growth factor; TIM-3: T-cell immunoglobulin and mucin domain-3; PD-1: Programmed Cell Death Protein 1; PD-L1: Programmed Cell Death Ligand 1; PGE2: Prostaglandin E2

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Cell Communication and Signaling

ISSN: 1478-811X