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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Exosomal lncRNA Mir100hg derived from cancer stem cells enhance glycolysis and promote metastasis of lung adenocarcinoma through mircroRNA-15a-5p/31-5p

Fig. 6

Mir100hg-miR-15a-5p/31-5p enhanced lung cancer metastasis through glycolysis. Levels of glucose, lactate and ATP in OE-Mir-100hg-LLC cells A and in OE-miR-15a-5p + 31-5p-OE-Mir-100hg-LLC cells B. mRNA levels of key rate-limiting enzymes of glycolysis in OE-Mir-100hg-LLC cells C and in OE-miR-15a-5p + 31-5p-OE-Mir-100hg-LLC cells; E Heat map of differential expression of key glycolytic enzymes in RNA-seq data of LLC-SD and LLC; F The migration and invasion of OE-Mir100hg-LLC treated with 1mM 2-DG for 20h; G migration and invasion of OE-miR-15a-5p + 31-5p-OE-Mir100hg-LLC treated with 25mM glucose for 20h; (H) Differential metabolite heatmap related to glycolysis and TCA in the untargeted metabolomics of OE-miR-15a-5p + 31-5p-OE-Mir100hg-LLC. (*p < 0.05, **p < 0.01, ***p < 0.001)

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Cell Communication and Signaling

ISSN: 1478-811X