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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Exosomal lncRNA Mir100hg derived from cancer stem cells enhance glycolysis and promote metastasis of lung adenocarcinoma through mircroRNA-15a-5p/31-5p

Fig. 2

lncRNA Mir100hg promotes the metastatic activity of lung cancer cells in vitro and in vivo. A Heatmap of differentially expressed genes in GSE66616 dataset, MIR100HG(Red); B Boxplot of MIR100HG expression differences between non-invasive lung cancer cells and invasive lung cancer cells and fibroblasts; C Boxplot of MIR100HG expression levels in non-invasive lung cancer cells after co-culture with different fibroblast cells; D Differences in Mir100hg expression between LLC-SD and LLC cells; E Differences in Mir100hg expression between the exosomes of LLC-SD and LLC’s; F LLC-SD-exosomes (labeled with PKH26, Red) could be delivered to LLC cells; G The expression of Mir100hg in the supernatant treated with RNase A (2mg/mL) alone or in combination with Triton X-100 (0.1%) for 20 min was analyzed by RT-PCR. H Expression of Mir100hg in LLC after co-incubation of LLC-SD-exosomes for 20h; I The efficiency of Mir100hg overexpression in LLC; J-K Column chart of migration and invasion cells; L Lung metastasis was observed after tail vein injection of OE-Mir100hg-LLC (green). M HE staining was used to observe and quantify lung metastases. (*p < 0.05, **p < 0.01, ***p < 0.001)

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Cell Communication and Signaling

ISSN: 1478-811X