Fig. 1

Effect of oleic acid on human platelet aggregation. A-J Washed platelets from human are pretreated with oleic acid or vehicle for 5 min in the presence of 1 mM CaCl₂ and stimulated with collagen (1 µg/mL), thrombin (0.08 U/mL), U46619 (0.12 µg/mL), CRP (0.05 µg/mL) and AA (0.5 mM); N = 5. K-L Platelet-rich plasma from human was pretreated with oleic acid or vehicle and stimulated with ADP (2.5 µM); N = 5. M-N Washed platelets from mice were pretreated with oleic acid or vehicle and stimulated with collagen (1 µg/mL); N = 5. Data are presented as mean ± standard error of mean; one-way analysis of variance; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, NS indicates no statistical significance