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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: RU.521 mitigates subarachnoid hemorrhage-induced brain injury via regulating microglial polarization and neuroinflammation mediated by the cGAS/STING/NF-κB pathway

Fig. 9

Schematic illustration of the possible mechanisms. Briefly, the activation of the cGAS/STING/NF-κB pathway was induced by subarachnoid hemorrhage, resulting in the expression of inflammatory genes and microglial activation. This activation led microglia to polarize towards the M1 phenotype, resulting in neuroinflammation through increased production of pro-inflammatory cytokines, which could ultimately worsen brain injury. RU.521 can regulate microglial polarization and reduce neuroinflammation, thereby mitigating these harmful effects. The figure was created with Biorender.com. Agreement number: TW25N2UE2X

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Cell Communication and Signaling

ISSN: 1478-811X