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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: RU.521 mitigates subarachnoid hemorrhage-induced brain injury via regulating microglial polarization and neuroinflammation mediated by the cGAS/STING/NF-κB pathway

Fig. 8

RU.521 inhibited microglial cGAS/STING pathway and the nuclear translocation of the p65 subunit of NF-κB in vitro. A, B Immunoblots analysis for the expression of cGAS, p-STING, STING, p-TBK1, and TBK1. n = 3 per group. C, D Immunoblots and quantitative analysis of the expression of p-IKBα and NF-kB p65. n = 3 per group. E Immunofluorescence staining for NF-kB p65 (red) and cell nuclei with DAPI (blue). Scale bar = 50 μm. *: P < 0.05, **: P < 0.01, ***: P < 0.001, and ****: P < 0.0001. ns, not significant

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Cell Communication and Signaling

ISSN: 1478-811X