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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: RU.521 mitigates subarachnoid hemorrhage-induced brain injury via regulating microglial polarization and neuroinflammation mediated by the cGAS/STING/NF-κB pathway

Fig. 4

RU.521 prompted microglial M1-to-M2 polarization and attenuated neuroinflammation via the cGAS/STING/NF-κB pathway. A-D Western blot bands and quantitative analysis of the expression of p-STING, STING, p-TBK1, TBK1, p-NF-κB p65, NF-κB p65, Arg-1, CD16, IL-10, IL-6, TNF-α, and IL-1β. n = 6 per group. E The representative pictures of immunofluorescence and quantitative analysis for pro-inflammatory cytokine TNF-α. Scale bar = 50 μm. n = 6 per group. *: P < 0.05, **: P < 0.01, ***: P < 0.001, and ****: P < 0.0001. ns, not significant

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Cell Communication and Signaling

ISSN: 1478-811X