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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: RU.521 mitigates subarachnoid hemorrhage-induced brain injury via regulating microglial polarization and neuroinflammation mediated by the cGAS/STING/NF-κB pathway

Fig. 3

RU.521 blunted the over-activation of microglia after SAH. A, B Western blot bands and quantitative analysis for Iba1 expression. n = 6 per group. C, D Immunofluorescence staining and quantitative analysis of activated microglia (Iba1). Scale bar = 100 μm. n = 6 per group. E Representative images of activated microglia (green) for the measurement of morphological parameters and (F) quantitative analysis with the area, perimeter, process length, fractal dimension, lacunarity, density, span ratio, and circularity. Scale bar = 50 μm. n = 6 per group. *: P < 0.05, **: P < 0.01, ***: P < 0.001, and ****: P < 0.0001. ns, not significant

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Cell Communication and Signaling

ISSN: 1478-811X