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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: RU.521 mitigates subarachnoid hemorrhage-induced brain injury via regulating microglial polarization and neuroinflammation mediated by the cGAS/STING/NF-κB pathway

Fig. 2

RU.521 was found to have a positive impact on neurological deficits, brain edema, BBB disruption, and neuronal damage 24 h after SAH. A, B The modified Garcia and beam balance scores of each group. n = 6 per group. C Quantification of brain water content at 24 h after SAH. n = 6 per group. D Quantification of Evans blue extravasation at 24 h after SAH. n = 6 per group. E Representative images of TUNEL staining (green) with neurons (NeuN, red). Scale bar = 100 μm. F Quantitative analysis of TUNEL-positive neuronal cells. n = 6 per group. G Representative images of Nissl staining. Scale bar = 100 μm. H Quantitative analysis of Nissl staining. n = 6 per group. *: P < 0.05, **: P < 0.01, ***: P < 0.001, and ****: P < 0.0001. ns, not significant

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Cell Communication and Signaling

ISSN: 1478-811X