Table 2 A summary of NKÂ cell-based clinical trials
Row | Study Title | Trial No | Interventions | Locations | Status |
|---|---|---|---|---|---|
1 | Ph1 Study of FT538 Alone and With Vorinostat for Persistent Low-Level HIV Viremia | NCT05700630 | Biological: FT538 Drug: Vorinostat | USA | Not yet recruiting |
2 | Allogeneic Natural Killer (NK) Cell Therapy in Subjects Hospitalized for COVID-19 | NCT04900454 | Biological: DVX201 | USA | Recruiting |
3 | Off-the-shelf NK Cells (KDS-1000) as Immunotherapy for COVID-19 | NCT04797975 | Biological: KDS-1000 Other: Placebo | Not yet been determined | Withdrawn |
4 | Fase I Clinical Trial on NK Cells for COVID-19 | NCT04634370 | Biological: NK Cells infusion | Brazil | Unknown status |
5 | Safety Infusion of NatuRal KillEr celLs or MEmory T Cells as Adoptive Therapy in COVID-19 pnEumonia or Lymphopenia | NCT04578210 | Biological: T memory cells and NK cells | Spain | Unknown status |
6 | Natural Killer Cell (CYNK-001) Infusions in Adults With COVID-19 | NCT04365101 | Biological: CYNK-001 | USA | Active, not recruiting |
7 | Study of FT516 for the Treatment of COVID-19 in Hospitalized Patients With Hypoxia | NCT04363346 | Drug: FT516 | USA | Completed |
8 | A Phase I/II Study of Universal Off-the-shelf NKG2D-ACE2 CAR-NK Cells for Therapy of COVID-19 | NCT04324996 | Biological: NK cells,IL15-NK cells,NKG2D CAR-NK cells,ACE2 CAR-NK cells,NKG2D-ACE2 CAR-NK cells | China | Unknown status |
9 | CMV Infection and Immune Intervention After Transplantation | NCT04320303 | Biological: expanded NK cells | China | Recruiting |
10 | NK Cells Treatment for COVID-19 | NCT04280224 | Biological: NK Cells | China | Recruiting |
11 | Long-term, Non-interventional, Observational Study Following Treatment With Fate Therapeutics FT500 Cellular Immunotherapy | NCT04106167 | Genetic: Allogeneic NK cell | USA | Recruiting |
12 | Adoptive Transfer of Haploidentical NK Cells and N-803 | NCT03899480 | Biological: Haploidentical NK Cells | USA | Completed |
13 | Adoptive Transfer of Haploidentical Natural Killer Cells and IL-2 | NCT03346499 | Biological: NK cells and IL-2 | USA | Completed |
14 | Immunotherapy of Natural Killer (NK) Cells in Human T Lymphotropic Virus Type 1(HTLV-1) Associated Myelopathy(HAM) | NCT02961712 | Biological: NK cells Biological: amniotic epithelial cells | China | Unknown status |