Fig. 6From: Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunitiesIntegrin-mediated Hippo signaling. Integrin senses the extracellular mechanical cues to regulate the on/off switch of Hippo signaling. The Hippo core kinase cascade may be dispensable in the process of YAP/TAZ nuclear translocation by integrin activation. However, Rho GTPases, particularly RhoA contributes to YAP/TAZ dephosphorylation via regulating actin cytoskeleton dynamicsBack to article page