Fig. 4
From: Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities
Integrin-mediated Rho GTPase signaling. Integrin associate with RTKs to mediate Rho GTPase subfamilies (RhoA, Rac and Cdc42) signaling via FAK-Src (integrin/RTKs) or ILK (integrin). Activation Rho GTPase signaling controls extension of lamellipodia and filopodia to form focal adhesions and actin stress fibers. Integrin association with the actin cytoskeleton by Rho GTPase is important for tumorigenesis and migration