Fig. 3
From: Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities
Integrin signaling network in cancer. Integrin interaction with RTKs mediates uncontrolled mitogenic and survival or uncontrolled actin assembly to regulate mitogenic signaling as well as related gene expression via FAK-Src (integrin/RTKs) or ILK (integrin) signaling. Activated integrin signaling controls cancer initiation and tumor growth, cancer cell adhesion and adhesion-induced migration, invasion and metastasis. It is associated with incidence and mortality of cancers