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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Roles of Twist1 in lipid and glucose metabolism

Fig. 2

Twist1 promotes renal fibrosis by regulating fatty acid oxidation (FAO). Twist1 regulates FAO through interacting with CPT1α and PGC-1α in adipose tissue and renal tubular cells, and acts as a key regulator of chronic inflammation and FAO in T helper cells. Administration of Rhein or Harmine could downregulate Twist1 expression thus rescue the development of kidney fibrosis

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Cell Communication and Signaling

ISSN: 1478-811X