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Fig. 13 | Cell Communication and Signaling

Fig. 13

From: Fasting-mimicking diet alleviates inflammatory pain by inhibiting neutrophil extracellular traps formation and neuroinflammation in the spinal cord

Fig. 13

Model showing the mechanism of FMD inhibiting NETs and relieving pain. NETs released by neutrophils in the spinal cord promote the development of pain by aggravating neuroinflammation. FMD inhibits both NETs formation and NETs-related neuroinflammation by downregulating MAO-B/5-HIAA/GPR35 and MAO-B/ROS pathways of astrocytes and neurons in the spinal cords of mice. FMD: fasting-mimicking diet

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Cell Communication and Signaling

ISSN: 1478-811X