Fig. 4
From: Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery
Mechanisms of linear ubiquitin and LUBAC in cancers. The mechanisms of LUBAC in cancers are roughly grouped into four types, as shown in the graph. ERα-, estrogen receptor-negative; DLBCL, diffuse large B-cell lymphoma; PTEN, phosphatase and tensin homolog; TC-PTP, T-cell protein tyrosine phosphatase; HIFα, hypoxia-induced factor α; YAP, Yes-associated protein; PPARγ, peroxisome proliferator-activated receptor γ; PKCζ, protein kinase C Zeta; MDM2, murine double minute 2; VHL, Von Hippel-Lindau protein; PRMT5, protein arginine methyltransferase 5. The figure was created with BioRender.com