Fig. 3
From: Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery
Linear ubiquitin-mediated signaling pathways. LUBAC catalyzes linear ubiquitin chains onto different substrates, and the linear ubiquitination leads to recruiting downstream signaling molecules, stabilizing target protein, and disrupting protein interaction. Each linear ubiquitin-mediated signaling pathway is discussed in detail in the main text. BCL10, the adaptor B cell CLL/lymphoma-10; BCR, B cell receptor; CARD11, scaffold caspase recruitment domain family member 11; cFLIP, cellular FLICE-like inhibitory protein; cIAP, cellular inhibitor of apoptosis; EGFR, epidermal growth factor receptor; FADD, FAS-associated death domain protein; IFN, interferon; IKK, IκB kinase; IL1R, interleukin 1 receptor type 1; IRAK, interleukin 1 receptor-associated kinase; IRF3, interferon regulatory factor 3; ISG, interferon-stimulated gene; JAK1, Janus kinase 1; MAVS, mitochondrial antiviral signaling protein; MyD88, myeloid differentiation primary response 88; NEMO, NF-κB essential modulator; NOD, nucleotide-binding oligomerization domain containing; OPTN, optineurin; PARKIN, Parkinson protein 2 E3 ubiquitin protein ligase; PKP2, plakophilin 2; RIG-I, retinoic acid-inducible gene I; RIPK, receptor-interacting protein kinase; STAT, signal transducer and activator of transcription; TCR, T cell receptor; TNFR, tumor necrosis factor receptor; TLR, Toll-like receptor; TRADD, TNFR1-associated death domain protein; TRAF, TNF receptor-associated factor; TYK2, tyrosine kinase 2. The figure was created with BioRender.com