Fig. 2
From: Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery
Domains and post-translational modification sites of the LUBAC subunits, OTULIN, and CYLD. CAP-Gly, cytoskeleton-associated protein glycine-rich; IBR, in-between RING; LDD, linear ubiquitin chain determining domain; LTM, LUBAC-tethering motif; OTU, ovarian tumor; PH, Pleckstrin-homology; PIM, PUB-interacting motif; PR, proline-rich region; PUB, PNGase/UBA or UBX; RING, really interesting new gene; UBL, ubiquitin-like; NZF, Npl4-type zinc finger; UBA, ubiquitin-associated; USP, ubiquitin-specific protease; ZF, zinc finger. The figure was created with BioRender.com