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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: TLR7 activation by miR-21 promotes renal fibrosis by activating the pro-inflammatory signaling pathway in tubule epithelial cells

Fig. 7

TLR7 inhibition alleviates renal fibrosis in a folic acid-treated mouse model. A Relative mRNA levels of fibrosis-related genes (Tgfb1, Col1a2, Col3a1, Acta2, and Vim) in the kidney of folic acid-treated mice with or without M5049 administration. #p < 0.05 versus control mice. *p < 0.05 versus folic acid-treated mice. B Protein levels of COL1 and αSMA in the kidneys were determined via western blotting. α-tubulin was used as a loading control. C Representative ISH images of Col1a1 (red) in the kidneys. Scale bar = 50 μm. D Representative IHC images of α-SMA in the kidneys. Scale bar = 50 μm. E Representative images of Sirius red (SR) staining in the kidney of folic acid-treated mice with or without M5049 administration. Scale bar = 50 μm. F Representative in situ hybridization (ISH) images of the Col1a1 (Green) and Emr1 (Red) genes in the kidney of folic acid-treated mice with or without M5049 administration. Scale bar = 50 μm

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Cell Communication and Signaling

ISSN: 1478-811X