A new perspective on mesenchymal stem cell-based therapy for liver diseases: restoring mitochondrial function

Cen, Yelei; Lou, Guohua; Qi, Jinjin; Zheng, Min; Liu, Yanning

doi:10.1186/s12964-023-01230-0

Cell Communication and Signaling

Table 1 Summary of the mitochondrial dysfunction modulation of MSCs in liver disease

From: A new perspective on mesenchymal stem cell-based therapy for liver diseases: restoring mitochondrial function

Liver disease	Mitochondrial dysfunction	Source	Delivery route	Potential mechanism	Ref
NAFLD	Abnormal lipid metabolism and calcium homeostasis	Human bone marrow	Intrasplenic injection	Mitochondrial transfer via TNT	[8]
NAFLD	Abnormal lipid metabolism and calcium homeostasis	Rat bone marrow	Tail vein	Restoring sarcoplasmic/ER Ca²⁺ ATPase activity to alleviate of ER stress	[46]
CCl₄-induced liver injury	Oxidant/antioxidant imbalance	Human bone marrow	Tail vein	Increasing SOD activity and inhibiting ROS production	[47]
CCl₄-induced liver injury	Oxidant/antioxidant imbalance	Human umbilical cord	Tail vein	Presented more distinct antioxidant by EVs	[48]
APAP and H₂O₂-induced liver injury	Oxidant/antioxidant imbalance	Rat bone marrow	Intrahepatic injection	Fractionated MSC exosomes reduce ROS activity more efficiently	[49]
APAP and H₂O₂-induced liver injury	Oxidant/antioxidant imbalance	Mouse adipose tissue	Tail vein	Increasing hepatic GSH level and alleviate ROS accumulation	[10]
D-galactose induced liver injury	Oxidant/antioxidant imbalance	Human umbilical cord	Tail vein	Reducing oxidative stress via activation of Nrf2/HO-1 pathway	[50]
Hepatic I/R injury	Oxidant/antioxidant imbalance	Human umbilical cord	Tail vein	Suppressing oxidative stress by MnSOD encapsulated in EVs	[21]
Hepatic I/R injury	Impaired mitophagy	Human umbilical cord	Peripheral vein	Reducing Parkin and PINK1 expression and inactivating AMPKα pathway	[22]
Post-hepatectomy liver failure	Impaired mitochondrial dynamics	Mouse bone marrow	Portal vein	Downregulating p-Drp1 and FIS1 expression and upregulating MFN2	[7]
Post-hepatectomy liver failure	Abnormal lipid metabolism	Mouse bone marrow	Portal vein	Reducing mitochondrial damage and secreting IL-10	[7]
Liver cirrhosis	Abnormal lipid metabolism	Human placenta	Tail vein	Attenuating ER stress via activating the EGFR-PI3K-CaM Pathway by PRL-1	[51]

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ISSN: 1478-811X

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