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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: A new perspective on mesenchymal stem cell-based therapy for liver diseases: restoring mitochondrial function

Fig. 2

The modification method applied to MSCs. Three modification techniques to improve the inherent therapeutic properties of MSCs in remodeling mitochondrial function were developed. a. Pretreating MSCs with a specifically designed cultural environment will increase the rate of survival and enhance immunoregulation. b. Genetic modifications such as overexpressing antioxidant genes have reliable therapeutic effects against mitochondrial dysfunction. c. Using the secretomes derived from MSCs carrying functional carriers such as miRNAs that can specifically restore mitochondrial function. Pretreated and gene-modified MSCs could also exert their effects through secretomes

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Cell Communication and Signaling

ISSN: 1478-811X