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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: A new perspective on mesenchymal stem cell-based therapy for liver diseases: restoring mitochondrial function

Fig. 1

Common mitochondrial dysfunctions in liver disease. In the liver, mitochondria are responsible for energy production and biological metabolism. ROS is a product of OXPHOS and excessive ROS causes damage to the mitochondria, which is observed in almost all liver diseases. In ALD and NAFLD, disturbances in lipid metabolism and calcium homeostasis are common mitochondrial dysfunctions. The mitochondrial quality control system maintains healthy mitochondrial turnover, which is driven by complex pathways involving DRP1, MFN1/2, OPA1, PINK1, and Parkin. An impaired quality control system is observed in ALD, hepatic I/R injury, hepatitis virus infection, and HCC

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Cell Communication and Signaling

ISSN: 1478-811X