Fig. 5

The spatiotemporal distribution of VPS37B and RAB27A at the embryo–maternal interface changed along with the progression of pregnancy. Representative immunofluorescence images displaying the untouched trophoblast–luminal epithelial interfaces and colocalization of VPS37B (yellow) and RAB27A (red) proteins. The nucleus is depicted in blue (DAPI). Trophectoderm attaches to the uterine luminal epithelium on days 12 (A) and 16 (C) of pregnancy. Uterine glands surrounded by stromal cells on days 12 (B) and 16 (D) of pregnancy. GL – glands, LE – luminal epithelium, T – trophectoderm, ST – stromal cells