Fig. 4
EIF3H depletion inhibits HCC proliferation and migration. A EIF3H repression inhibited cell proliferation in HCC cells. B Knockdown of EIF3H-induced G1 cell cycle arrest in HCC cells. C Silence of EIF3H decreased clone formation capability of HCC cells. D-E Representative images of EdU assays of LM3 and Hep3B cells. F Transwell invasion assay of HCC cells. G-H EIF3H depletion inhibits tumor growth in vivo. LM3 cells were stably transfected with lentivirus carrying a scrambled shRNA or EIF3H shRNA. 1 × 106 LM3 cells were injected into each mouse (n = 6). Tumor sizes were measured every five days until the end of the experiment. ***P value < 0.001