Fig. 8

Therapeutic benefit of CoQ10 on mitochondrial function and restoring cardiac function in diabetic MI/R injury. A-D Total ATP production and ETC complex activity in cardiomyocytes. E–F Seahorse exhibited the alterations in respiratory capacity. G Representative protein level of DRP1 was detected by western blotting. H Quantification of H. All data are presented as mean ± SEM. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001. I Representative EM images of mitochondrial morphology. Scale bar: 10 μm. Yellow arrow: lipid droplets. Red arrow: damaged mitochondria. J-K Left ventricular ejection fraction and fractional shortening (n = 10). Data are presented as mean ± SEM. ^*P < 0.05, ^***P < 0.001, ^****P < 0.0001. L Representative images of HE-stained heart sections after MI/R or sham operation. Section scale bar: 1 μm. Zoom scale bar: 200 μm. M Representative images of Evans blue and TTC stained heart sections after MI/R or sham operation. Scale bar: 4 mm