Fig. 7
STING inhibition abrogates inflammation response in diabetic MI/R injury. A LDH level. B Cell viability. C and I mRNA levels of NLRP3, TNF-α, and IL-1β were detected using qRT-PCR. D Representative protein levels of p-TBK1s172 and TBK1 detected by western blotting. E Quantification of D. F–H Left ventricular ejection fraction and fractional shortening. (n = 10). J Representative images of Evans blue and TTC stained heart sections after MI/R or sham operation. Scale bar: 4 mm. K Representative images of HE-stained heart sections after MI/R or sham operation. Section scale bar: 1 μm. Magnified scale bar: 200 μm. All data are presented as the mean ± SEM. *P < 0.05,**P < 0.01, ***P < 0.001,****P < 0.0001