Fig. 1

Diabetic model successfully, MI/R injury increased damaged DNA. A Animal experiment process. B Body weight of ND-fed and HFD-fed. C57BL/6 J mice were set on either 60% HFD, or normal diet to serve as a control. Results are mean ± SEM. ^*** P < 0.001, n = 50. C Glucose levels during IPGTT. Results are mean ± SEM. ^** P < 0.01, ^*** P < 0.001. n = 50. D Glucose area under the curve (AUC) during IPGTT. The blood glucose level measured at each time period subtracted the baseline blood glucose gave the corrected AUC. An AUC higher than the baseline glucose indicated glucose resistance in the HFD-fed mice. E Insulin levels during IPGTT. Results are mean ± SEM. ^*** P < 0.001, n = 50. F Glucose levels during ITT. Results are mean ± SEM. ^* P < 0.05, ^*** P < 0.001. n = 50. G Glucose area under the curve during ITT. After correction, the blood glucose level is multiplied -1. Results are mean ± SEM. ^*** P < 0.001. n = 50. H Representative Evans blue and TTC stained sections after MI/R injury. I Infarct/area at risk% (IA/AAR%). n = 6, Results are mean ± SEM. ^** P < 0.01 versus ND + MI/R group. J The expression of 8-OHdG