Table 1 ncRNAs in keloid fibroblasts
miRNA | Expression | Targets | Mechanism |
|---|---|---|---|
miRNA-21 | Up | Smad7 [61]; | Promote collagen production |
miRNA-21-5p | Up | PTEN [62]; | Promote KF autophagy and migration |
miRNA-152-3p | Up | FOXF1 [63]; | Promote cell proliferation and ECM-related protein expression |
miRNA-31 | Up | HIF1AN [64]; | Promote KF proliferation and decrease KF apoptosis |
miRNA-203 | Down | EGR1 and FGF2 [65] | Inhibit KF proliferation, invasion, and ECM production |
miRNA-205 | Down | VEGF [66] | Inhibit the PI3K/Akt pathway |
miRNA-637 | Down | Smad3 [67] | Inhibit KF proliferation and metastasis |
miRNA-29a | Down | TGF-β1 [68] | Decrease type I and type III collagen mRNA and protein levels |
LncRNA | Expression | Targets | Mechanism |
CACNA1G-AS1 | Up | miR-205 [69] | Suppress miR-205 expression to promote keloid progression |
HOXA11-AS | Up | miR-148b-3p [70] | Abrogate the inhibition of IGFBP5 mRNA by targeting miR-148b-3p |
LINC01116 | Up | miR-203 [71] | Promote keloid progression via miR-203/SMAD5 axis |
LINC00937 | Down | miR-28-5p [72] | Act as an miR-28-5p sponge, promote MC1R expression |
LncRNA H19 | Up | miR-196b-5p; miR-214-5p [73] | Promote SMAD5 expression, enhance anaerobic glycolysis of KFs |
CircRNA | Expression | Targets | Mechanism |
CircNRIP1 | Up | FXR1 [74] | Promote miRNA‑503 maturation |
CircPTPN12 | Up | miRNA-21-5p [75] | Activate Wnt signaling pathway |
Circ_101238 | Up | miR-138-5p [76] | Promote keloid progression via the miR-138-5p/CDK6 axis |
circCOL5A1 | Up | miR-877-5p [77] miR-7-5p [78] | Inhibit the miR-877-5p/EGR1 axis, activate the PI3K/Akt signaling pathway |
CircPDE7B | Up | miR-661 [79] | Promote keloid progression by the circPDE7B/miR-661/FGF2 pathway |
Circ_0057452 | Up | miR-7-5p [80] miR-1225-3p [81] | Promote keloid progression via the miR-7-5p/GAB1 axis; promote keloid progression by targeting miR-1225-3p and regulating AFF4 levels |