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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Inhibition of ERK downregulates autophagy via mitigating mitochondrial fragmentation to protect SH-SY5Y cells from OGD/R injury

Fig. 8

The expression of p-ERK, p-Drp1 and LC3II at different time points of OGD/R. A Multiple immunofluorescence images of p-ERK (green), p-Drp1 (pink) and LC3II (red) proteins at OGD1h/2 h/3 h reoxygenation 24 h, and OGD2h reoxygenation 12 h/24 hrs/36 hrs. Nuclei were stained with Dapi (blue), scare bar: 50 μm. Detail represents the enlarged view of the rectangles in Merge. B-D, Quantitative analysis of p-ERK, p-Drp1 and LC3II expression. All data in this figure are representative of three independent repeats and are shown as mean ±SEM. OGD1h/2 h/3 h: oxygen-glucose deprivation 1 h/2 hrs/3 hrs and reoxygenation 24 h; R12h/24 h/36 h: oxygen-glucose deprivation 2 h and reoxygenation 12 h/24 hrs/36 hrs. *P < 0.05 vs. Control

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Cell Communication and Signaling

ISSN: 1478-811X