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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Inhibition of ERK downregulates autophagy via mitigating mitochondrial fragmentation to protect SH-SY5Y cells from OGD/R injury

Fig. 4

Inhibition of ERK alleviates p-Drp1S616 dependent mitochondrial fission and injury after OGD/R in SH-SY5Y cells. A Representative immunoblot bands of p-Drp1 and Drp1; B, C, Quantitative analysis of p-Drp1 and Drp1; D, Transmission electron microscopy images of mitochondria, the red arrows shows the mitochondria; E, Quantitative analysis of mitochondrial area. All data in this figure are representative of three independent repeats and are shown as mean ±SEM. si-NC: Drp1 si-RNA negative control group; si-751/si-843/si1684: Drp1 si-RNA sequences; Drp1S616E: Drp1S616E-GFP-M90 plasmid; Vector: Drp1S616E negative control group. *P < 0.05 vs. Control, #P < 0.05 vs. si-NC, &P < 0.05 vs. si-843, $P < 0.05 vs. si-1684, @P < 0.05 vs. PD + si-NC

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Cell Communication and Signaling

ISSN: 1478-811X