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Fig. 12 | Cell Communication and Signaling

Fig. 12

From: Inhibition of ERK downregulates autophagy via mitigating mitochondrial fragmentation to protect SH-SY5Y cells from OGD/R injury

Fig. 12

The schematic of hypothesis for ERK-mitochondrial fragmentation-autophagy axis-mediated OGD/R-induced injury in SH-SY5Y cells. Inhibition of ERK downregulates autophagy via ameliorating Drp1/Mfn2-dependent mitochondrial fragmentation, recovering mitochondrial function and reducing neuron death. OGD/R: Oxygen glucose deprivation/reoxygenation; p: Phosphorylation; ERK: Extracellular signal-regulated kinase; Drp1: Dynamin-related protein 1: Mfn2: Mitofusin2; LC3: Microtubule-associated protein light chain 3; Beclin1: BECN 1; p62: Sequestosome 1; mPTP: Mitochondrial permeability transition pore

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Cell Communication and Signaling

ISSN: 1478-811X