Fig. 10

Inhibition of ERK downregulates autophagy through increasing Mfn2 in OGD/R-treated SH-SY5Y cells. A Representative immunoblot bands of LC3B, Beclin1 and p62. B-D, Quantitative analysis of expression of LC3B, Beclin1 and p62. All data in this figure are representative of three independent repeats and are shown as mean ±SEM. E The transmission electron microscopy images of autophagosomes/autolysosomes (red arrows). Scare bar: 1 μm. si-Mfn2(C): Mfn2 si-RNA without OGD/R group; PD: PD98059 group; Mfn2: Mfn2 si-RNA group. *P < 0.05 vs. Control, #P < 0.05 vs. Model, &P < 0.05 vs. PD