Table 1 List of chemotherapeutic agents targeting breast cancer pyroptosis

xihuang pill (XHP) [99]

cAMP / PKA

Regulation of cAMP/PKA signaling pathway upregulates caspase-1,GSDMD

dihydroartemisinin (DHA) [100]

AIM2/ caspase-3/DFNA5

AIM2 activation causes cleavage of caspase-3, which in turn increases the expression of DFNA5

Quercetin [101]

PYD, ASC, NLRP3

Down-regulation of PYD, ASC, NLRP3, and inhibition of caspase-1 expression

Docosahexaenoic acid (DHA) [102]

caspase-1, gasdermin D

caspase-1 activates the cleavage of gasdermin D and increases the release of IL-1β

Benzenesulfonimide PPARα antagonists [103]

caspase-3, PPAR, Nrf2

Increases caspase-3 cleavage, affects the Nrf2/PPARα molecular axis, and increases superoxide anion production

nobiletin [104]

miR-200b/JAZF1\/NF-κB

Promoting miR-200b overexpression inhibits JAZF1 while promoting activation of NF-κB and GSDMD

andrographolide (ANDR) [105]

caspase-8

activation of caspase-8, FLIP (FLICE-like inhibitory protein) and XIAP (X-linked apoptosis inhibitory protein)

tubulysins [106]

caspase-3, GSDME

Antibody drug conjugate (ADC) therapy co-administered tubulysins to promote caspase-3 cleavage of GSDME

3-acyl isoquinolin-1(2H)-one [107]

GSDME

Induction of G2 phase block, apoptosis and GSDME-mediated pyroptosis in breast carcinoma

Triclabendazole [108]

caspase-3, GSDME

Activation of caspase-3 induces GSDME-dependent pyroptosis

RIG-I Agonists [109]

caspase-1, caspase-10

Activation of caspase-1 to cleave GSDMD

Spatholobus suberectus Dunn percolation extract (SSP) [110]

caspase-4, caspase-9, GSDME

Upregulation of inflammatory vesicles and ROS, activation of caspase-4 and caspase-9 cleavage of GSDME

Ganoderma lucidum extract (GLE) [111]

caspase-3, GSDME

Activates caspase-3/GSDME signaling pathway and induces immune response

Tetraarsenic hexoxide [112]

ROS, GSDME

Increased ROS production and GSDME-mediated pyroptosis