Fig. 2
From: Effect of tumor-associated macrophages on the pyroptosis of breast cancer tumor cells
The breast tumor microenvironment regulates TAM in different aspects and the nteraction of TAM with breast tumor cells. There are four main areas. 1) Polarization, regulation of M1 polarization by IFN-γ, LPS, GM-CSF, and M2 polarization by CSF-1, TGF-β, IL-4, IL-10, IL-13; 2) recruitment, recruitment of TAM via CSF1, CX3CL1, CCL2; 3) tumor angiogenesis, VEGF, IL-1, Metalloproteinase to promote blood vessel growth. (4) Regulation of TAM phagocytosis by modulating CRT/LRP, LILRB1/β2-MG, CD47/SIRPα, PD-1 / PD-L1 affects TAM phagocytosis.The yellow dashed box depicts the interaction between TAM and breast cancer cells, and the effect of T cells on breast cancer tumor cells