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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: GDF-11 downregulates placental human chorionic gonadotropin expression by activating SMAD2/3 signaling

Fig. 5

SMAD2 and SMAD3 are involved in the GDF-11-induced downregulation of CGB expression. A and B BeWo cells were transfected with 50 nM control siRNA (si-Ctrl), SMAD2 siRNA (si-SMAD2), or SMAD3 siRNA (si-SMAD3) for 48 h, and then treated with 10 ng/mL GDF-11 (G11) every 24 h for 48 h. The mRNA (A) and protein (B) levels of CGB, SMAD2, and SMAD3 were examined by RT-qPCR and western blot, respectively. The results are expressed as the mean ± SEM of at least three independent experiments. The values without a common letter are significantly different (p < 0.05)

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Cell Communication and Signaling

ISSN: 1478-811X