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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Hepatocellular carcinoma cells remodel the pro-metastatic tumour microenvironment through recruitment and activation of fibroblasts via paracrine Egfl7 signaling

Fig. 2

CAFs are frequently presented in HCC tissues and are associated with poor clinical characteristics and unfavourable prognosis in HCC patients. A Immunohistochemistry staining showed CAFs in HCC tissues, adjacent nontumourous liver tissues (ANLTs) and distant nontumourous liver tissues (DNLTs). B Immunohistochemistry staining showed CAFs in tumour tissues and DNLTs of nodular hepatocellular carcinoma (NHCC) and solitary large hepatocellular carcinoma (SLHCC). C Statistical analysis of CAFs in HCC tumour tissues with/without microvascular invasion (MVI) and with/without early recurrence (ER). D, E Kaplan–Meier analysis of overall survival, disease-free survival and early recurrence of HCC patients with high or low CAF infiltration in the training cohort (D) and validation cohort (E). **P < 0.01; ***P < 0.001

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Cell Communication and Signaling

ISSN: 1478-811X