Role of tRNA-derived small RNAs(tsRNAs) in the diagnosis and treatment of malignant tumours

Mao, Mingwen; Chen, Weina; Huang, Xingbiao; Ye, Dong

doi:10.1186/s12964-023-01199-w

Cell Communication and Signaling

Table 1 The roles and possible mechanisms of tsRNAs in malignant tumors

From: Role of tRNA-derived small RNAs(tsRNAs) in the diagnosis and treatment of malignant tumours

Cancer types	tsRNA	type	Expression level	Biological function	Downstream regulators	Target molecules	Predictive use	References
Papillary thyroid cancer	tRF39- 0VL8K87SIRMM12E2	tRF	UP	Regulation of tumor cell proliferation	—	—	Biomarkers for diagnosis	[34]
Papillary thyroid cancer	tiRNA-Gly	tiRNA	UP	Regulation of tumor cell proliferation and migration	RBM17	MAP4K4	Biomarkers for diagnosis and targeted therapy	[35]
Nasopharyngeal carcinoma	tRF1: 28 -Val-CAC-2	tRF	UP	Regulation of tumor cell proliferation and migration	AGO3	—	Biomarkers for diagnosis	[36]
Laryngeal squamous cell carcinoma	tRF-33-Q1Q89P9L842205	tRF	UP	Regulation of tumor cell proliferation and invasion, migration	PIK3CD	—	Biomarkers for diagnosis and targeted therapy	[37]
Lung adenocarcinoma	tsRNA-5001a	tRF	UP	Regulation of tumor cell proliferation	GADD45G	—	Biomarkers for diagnosis and targeted therapy	[48]
Non small cell lung cancer (NSCLC)	tRF-LeuCAG	tRF	UP	Regulation of tumor cell proliferation and cell cycle	AURKA	—	Biomarkers for diagnosis and targeted therapy	[27]
Non small cell lung cancer (NSCLC)	AS-tDR-007333	tRF	UP	Regulation of tumor cell proliferation and migration	HSPB1/ELK4	MED29	Biomarkers for diagnosis and targeted therapy	[65]
Hepatocellular carcinoma	LeuCAG3'tsRNA	tRF	Down	Regulation of tumor cell proliferation	RPS28/RPS15	—	Biomarkers for diagnosis and targeted therapy	[18]
Gastric cancer	tRF-5026a	tRF	Down	Regulation of tumor cell proliferation, migration, and cell cycle progression	PTEN/PI3K/AKT	—	Biomarkers for diagnosis and targeted therapy	[49]
Gastric cancer	tiRNA-Val-CAC-001	tiRNA	Down	Regulation of tumor cell proliferation and migration	LRP6	—	Biomarkers for diagnosis	[66]
Colorectal cancer	5’-tiRNA-Val	tiRNA	Up	Regulation of tumor cell invasion and metastasis	—	—	Biomarkers for diagnosis and targeted therapy	[62]
Gastric cancer	tRF-Glu-TTC-027	tRF	Down	Regulation of tumor cell proliferation and invasion and metastasis	MAPK	—	Biomarkers for diagnosis and targeted therapy	[40]
Prostatic cancer	tRF-1001	tRF	Down	Regulation of tumor cell proliferation	—	—	Biomarkers for diagnosis and targeted therapy	[28, 55]
Breast cancer	5’-tiRNAVal	tiRNA	Down	Regulation of tumor cell proliferation	FZD3	—	Targeted therapy	[57]
Breast cancer	tsRNA-26576	tRF	Up	Regulation of tumor cell proliferation and invasion and metastasis	SPEN/FAT4	—	Biomarkers for diagnosis	[45]
Breast cancer	Ts-57 s、ts-46 s	tRF	Up	Regulation of chemoresistance in tumor cells	—	—	Targeted therapy	[60]
High grade ovarian cancer	tRF03357	tRF	Up	Regulation of tumor cell proliferation, migration and invasion	HMBOX1	—	Biomarkers for diagnosis	[46]
Cervical carcinoma	tRFGlu49	tRF	Down	Regulation of tumor cell proliferation, migration and invasion	FGL1	—	Biomarkers for diagnosis and targeted therapy	[58]
High-grade serous ovarian cancer (HGSO)	tiRNA-Gln-CTG-003、tiRNA-His- GTG001	tiRNA	Up	Regulation of tumor cell proliferation	—	—	Biomarkers for diagnosis and targeted therapy	[56]
Glioblastoma cells	ts-N22	tRF	Down	Regulation of tumor cell metastasis	Hsa-mir-331/ Hsa-mir-33a	Neurocortin-2	Targeted therapy	[54]
Osteosarcoma	5′ tsRNAAla, 5′ tsRNACys	tRF	Down	Regulation of tumor cell proliferation	RG4	—	Targeted therapy	[9]
B cell chronic lymphocytic leukemia (CLL)	tsRNA-53	tRF	Down	Regulation of tumor cell proliferation	TCL1	—	Targeted therapy	[59]
Multiple myeloma	TRF-60:76-Arg-acg1-m2	tRF	Down	Regulation of tumor cell proliferation	—	—	Biomarkers for diagnosis	[47]

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ISSN: 1478-811X

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