Fig. 5
From: Intrinsic disorder in PRAME and its role in uveal melanoma
Evaluation of redox-sensitive disorder predispositions of PRAME by IUPred2A_redox. The corresponding plot shows the disorder profile for the reduced (redox-minus) and oxidized (redox-plus) forms of a protein by violet and red lines, respectively. Shaded areas (not seen in PRAME) represent significant redox-sensitive regions. The C-terminus of PRAME (region is from amino acids 475 to 509) is a non-significant redox-sensitive, conditionally disordered/flexible region (i.e., a region that undergoes disorder-to-order transition (DOT) in a redox-sensitive manner). In its reduced state (redox-minus), the C-terminus is not highly disordered but flexible, characterized by an IUPred average disorder score (ADSIUPredredox) of 0.35 ± 0.11. In its reduced state (redox-plus), the C-terminus region is highly ordered (ADS.IUPredredox = 0.059 ± 0.035)