Fig. 4
From: Intrinsic disorder in PRAME and its role in uveal melanoma
The D2P2 platform output assesses the functional disorder profile for PRAME. On the figure's left are four identifiers for predictors used on the D2P2 platform. The top right of the figure shows outputs from various per-residue disorder predictors (i.e., Espritz-D, Espritz-X, Espritz-N, IUPred-L, IUPred-S, PV2, PrDOS, VSL2b, VLXT); the second bracket shows predicted protein domains, the third bracket shows where molecular recognition features are located (MoRFs; i.e., disorder regions that become ordered when binding), and the fourth bracket shows posttranslational modifications (PTM) sites. The protein domains fall within regions predicted to be ordered or disordered. The MoRF regions are localized to regions that demonstrate extensive disorder. The PTMs are also predominantly localized to areas of each protein that contain intrinsic disorder